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KMID : 0978920100110040307
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Korean Journal of Clinical Geriatrics
2010 Volume.11 No. 4 p.307 ~ p.314
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Correlation between Neuroelectrophysiological Findings and Sensory Symptoms in Patients with Idiopathic Parkinson Disease
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Cho A-Ra
Song In-Uk
Kim Young-Do
Chung Sung-Woo
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Abstract
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Background: Idiopathic Parkinson’s disease (IPD) is a neurodegenerative disorder involving the basal ganglia and it is thought to spare the peripheral nervous system. And there is little evidence associating peripheral neuropathy and IPD in the current literature However, ambiguous sensory symptoms including pain and numbness have been a well recognized nonmotor manifestation of IPD that affect between 40% and 75% of patients during their illness. Thus, we invested to clarify association peripheral neuropathy and IPD associated with sensory symptoms by using electrophysiological tests.
Methods: We recruited 25 patients with IPD associated with ambiguous sensory symptoms, such as pain, numbness and hypoesthesia. All IPD patients were performed modified Hoehn and Yahr Stage (H & Y stage) to evaluate severity of motor symptoms of IPD and electrophysiological tests to clarify presence of neuropathy. We also categorized all patients into 2 groups according to H & Y stage(group I=H & Y stage I and II; group II=H & Y stage III and IV) and analyzed correlation between severity of IPD and peripheral nerve disorder.
Results: Nerve conduction tests of our study demonstrated abnormal findings on sensory amplitude of ulnar nerve and nerve velocity of posterior tibial motor nerve, significantly. Our study showed no association between electrophysiological findings and motor severity of Parkinson’s disease according to H & Y stage but significant correlation between levodopa dosage and electrophysiological findings.
Conclusion: In this study, we could show that IPD patents with sensory symptoms might have elelctrophysiological abnormalities and there was not association between motor severity and electrophysiological
findings but association between levodopa dosage and electrophysiological findings. Therefore, we cautiously suggest that IPD is neurodegenerative disease involving peripheral nerve system as nonmotor symptoms, which was associated with levodopa dosage per day.
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KEYWORD
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Parkinson’s disease, Sensory symptoms, Peripheral neuropathy
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